Can the Notch Pathway be Targeted for Cancer Therapy?
Yes, the Notch pathway is a promising target for cancer therapy. Various therapeutic strategies are being explored, including:
- Gamma-secretase inhibitors (GSIs): These inhibitors prevent the cleavage and activation of Notch receptors, thereby blocking the pathway. - Monoclonal antibodies: Targeting Notch receptors or ligands to inhibit their interaction. - Small molecule inhibitors: These compounds can disrupt the Notch transcriptional activation complex. - RNA interference: Silencing Notch pathway genes using siRNA or shRNA.
