What are the Challenges in Targeting the Notch Pathway?
Despite the potential, several challenges exist in targeting the Notch pathway:
- Toxicity: Systemic inhibition of Notch can lead to gastrointestinal toxicity and other side effects due to its role in normal tissue homeostasis. - Resistance: Cancer cells may develop resistance to Notch inhibitors through compensatory pathways or mutations. - Tumor heterogeneity: The varying roles of Notch in different cancer types and even within the same tumor complicate treatment strategies.
