notch pathway

Which Types of Cancer are Associated with Notch Pathway Deregulation?

Notch pathway deregulation is associated with several types of cancer, including:
- T-cell acute lymphoblastic leukemia (T-ALL): Activating mutations in Notch1 are frequently observed.
- Breast cancer: Overexpression of Notch receptors and ligands has been linked to poor prognosis.
- Lung cancer: Notch signaling contributes to cancer cell survival and resistance to therapies.
- Colorectal cancer: Notch1 and Notch2 have been implicated in the progression and metastasis.
- Pancreatic cancer: Notch signaling promotes cancer stem cell maintenance and tumorigenesis.

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