The Notch pathway is a highly conserved cell signaling system present in most multicellular organisms. It plays a crucial role in cell differentiation, proliferation, and apoptosis. The pathway involves interactions between the Notch receptors (Notch1, Notch2, Notch3, and Notch4) and their ligands (Jagged and Delta-like families), leading to the release of the Notch intracellular domain (NICD) that translocates to the nucleus to regulate gene expression.