Can TNFR1 signaling be targeted for cancer therapy?
Yes, TNFR1 signaling can be targeted for cancer therapy. Inhibitors of TNF or TNFR1 have been explored as potential therapeutic strategies to reduce inflammation and tumor growth. However, due to the dual role of TNFR1 in promoting both cell death and survival, targeting this pathway requires a nuanced approach to avoid unintended consequences.
