What are the challenges in targeting TNFR1 in cancer therapy?
One of the main challenges in targeting TNFR1 is its dual role in cancer. Inhibiting TNFR1 signaling might reduce tumor-promoting inflammation but could also impair the immune system's ability to induce cancer cell apoptosis. Additionally, TNFR1 inhibitors might have systemic effects, leading to unwanted side effects such as immunosuppression and increased susceptibility to infections.
