Have there been any Clinical Trials Involving shRNAs in Cancer?
Yes, several clinical trials have explored the use of shRNAs in cancer treatment. For instance, some trials have investigated the use of shRNAs to target Bcl-2 in lymphoma, a protein that helps cancer cells evade apoptosis. Other trials have focused on silencing VEGF to inhibit angiogenesis in solid tumors. While many of these trials are still in early phases, the results so far have been promising, showing the potential for shRNAs to become a viable component of cancer therapy.
