What Challenges are Associated with shRNA-Based Cancer Therapies?
Despite their potential, shRNA-based therapies face several challenges. One major issue is off-target effects, where shRNAs inadvertently silence genes other than their intended targets, potentially causing unwanted side effects. Another challenge is the delivery efficiency and stability of shRNAs within the body. Ensuring that shRNAs reach the target cancer cells in sufficient quantities without being degraded or eliciting an immune response remains a significant hurdle.
