What is the Role of the Tumor Microenvironment in EMT?
The tumor microenvironment plays a pivotal role in regulating EMT. Factors secreted by stromal cells, immune cells, and the extracellular matrix can influence the EMT process. The interaction between cancer cells and the microenvironment is bidirectional; while the microenvironment can induce EMT in cancer cells, the cancer cells undergoing EMT can also remodel the surrounding microenvironment to support their invasive and metastatic behavior.
