How are miRNA sponges different from other miRNA-targeting therapies?
miRNA sponges differ from other miRNA-targeting therapies, such as antisense oligonucleotides (ASOs) and small molecule inhibitors, in several ways. While ASOs and small molecules typically inhibit miRNA function by directly binding to the miRNA or its precursor, miRNA sponges act as decoys, sequestering multiple miRNAs simultaneously. This allows for the modulation of entire miRNA families, potentially resulting in more comprehensive therapeutic effects. Additionally, miRNA sponges can be engineered to have high specificity, reducing off-target effects compared to other therapies.
