How Can Epigenetic Changes Be Targeted for Cancer Therapy?
Epigenetic changes are reversible, making them attractive targets for cancer therapy. Current strategies include:
- DNA methyltransferase inhibitors (e.g., azacitidine and decitabine) that reverse abnormal DNA methylation. - Histone deacetylase inhibitors (e.g., vorinostat and romidepsin) that alter histone acetylation and gene expression. - Drugs targeting non-coding RNAs to restore normal gene expression patterns.
