How Do Actin Binding Proteins Influence Cancer Progression?
ABPs influence cancer progression by affecting cell motility, invasion, and metastasis. Cofilin, a well-known ABP, facilitates actin filament turnover, enhancing cell motility. Overexpression of cofilin has been linked to increased metastatic potential in various cancers. Similarly, gelsolin, another ABP, is involved in actin filament severing and remodeling. Its altered expression is associated with several cancer types, including breast and prostate cancer.
