What Is the Role of ABPs in Cell Signaling Pathways?
ABPs are not only structural proteins but also mediators of cell signaling pathways. They interact with signaling molecules such as kinases and phosphatases, influencing pathways that regulate cell growth and survival. For instance, the ABP profilin binds to phosphatidylinositol (4,5)-bisphosphate (PIP2), impacting the PI3K/AKT signaling pathway, which is often dysregulated in cancer.
