What types of RAD50 mutations are associated with cancer?
RAD50 mutations can be classified into several types, including missense, nonsense, and frameshift mutations. Missense mutations result in a single amino acid change, potentially altering the protein's function. Nonsense mutations can create a premature stop codon, leading to a truncated and usually non-functional protein. Frameshift mutations, caused by insertions or deletions, can disrupt the reading frame of the gene, resulting in a dysfunctional protein. Each of these mutation types can compromise the role of RAD50 in DNA repair, contributing to cancer development.
