What are the therapeutic implications of RAD50 mutations?
Understanding RAD50 mutations can inform therapeutic strategies. For instance, cells with impaired DNA repair due to RAD50 mutations might be more sensitive to certain types of chemotherapy that induce DNA damage, such as platinum-based drugs. Additionally, PARP inhibitors, which target other DNA repair pathways, have shown promise in treating cancers with defective homologous recombination repair, including those with RAD50 mutations. Identifying RAD50 mutations can thus guide personalized treatment approaches and improve patient outcomes.
