How Do Chromosomal Abnormalities Influence Cancer Treatment?
Understanding chromosomal abnormalities can significantly impact cancer treatment strategies. For instance, targeted therapies have been developed to specifically address genetic abnormalities:
Imatinib: Targets the BCR-ABL fusion protein in CML resulting from the Philadelphia chromosome. All-trans Retinoic Acid (ATRA): Used in APL to target the PML-RARA fusion protein. Rituximab: Targets CD20 on B-cells in certain lymphomas with specific chromosomal abnormalities.
