How Do Endothelial Cells Contribute to Cancer Progression?
In the context of cancer, endothelial cells contribute to tumor progression by facilitating tumor angiogenesis. Tumors require a blood supply to receive nutrients and oxygen and to remove waste products. This is achieved through the formation of new blood vessels from pre-existing ones, a process heavily mediated by endothelial cells. Tumor cells secrete various pro-angiogenic factors such as Vascular Endothelial Growth Factor (VEGF), which stimulate endothelial cells to proliferate and form new blood vessels, thereby sustaining tumor growth.
