What Are the Challenges in Targeting Endothelial Cells in Cancer Therapy?
While targeting endothelial cells in cancer therapy has shown promise, there are several challenges. One major issue is the development of resistance to anti-angiogenic therapies. Tumors can adapt by activating alternative angiogenic pathways or by increasing the invasiveness and metastatic potential of cancer cells. Additionally, anti-angiogenic therapies can lead to side effects such as hypertension, bleeding, and impaired wound healing.
