How do HER3 and HER4 contribute to cancer progression?
HER3 and HER4 contribute to cancer progression through their ability to activate critical signaling pathways. HER3, often in partnership with HER2, activates the PI3K/AKT pathway, promoting cell survival and proliferation. This dimerization can lead to resistance against therapies targeting HER2 or EGFR. HER4's role in cancer is more complex; it can act as both a tumor suppressor and an oncogene, depending on the cellular context and specific isoforms expressed.
