Are there therapeutic strategies targeting HER3 and HER4?
Yes, several therapeutic strategies are being explored to target HER3 and HER4. For HER3, inhibitors and monoclonal antibodies are in development. One example is the antibody-drug conjugate U3-1402, which targets HER3 and has shown promising results in early clinical trials. HER4-targeted therapies are less developed but include small molecule inhibitors and antibodies aimed at specific HER4 isoforms or mutations. Combining HER3 or HER4 inhibitors with other targeted therapies may offer a more effective treatment strategy.
