What alterations are seen in HER3 and HER4 in cancer?
Alterations in HER3 and HER4 can include overexpression, mutations, and alternative splicing. HER3 overexpression is often observed in breast, gastric, and lung cancers, and is associated with poor prognosis and resistance to therapy. HER4 alterations, including mutations and changes in expression levels, have been reported in melanoma, breast, and non-small cell lung cancer. These alterations can either enhance or inhibit tumor growth depending on the context and specific cancer type.
