LHRH agonists initially stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a temporary surge in testosterone or estrogen levels. However, with continuous use, they cause a downregulation of LHRH receptors in the pituitary gland. This downregulation ultimately leads to a significant reduction in the production of sex hormones, creating a state similar to surgical castration, also known as chemical castration.
