LPA1 is implicated in the progression of several types of cancer. Its overexpression or dysregulation can lead to enhanced tumorigenesis and metastasis. LPA1 signaling promotes tumor cell proliferation by activating pathways like the PI3K/Akt and MAPK/ERK pathways. It also facilitates cancer cell migration and invasion, which are critical steps in metastasis. Additionally, LPA1 can contribute to the cancerous microenvironment by promoting angiogenesis and modulating immune responses.
