RhoA plays a significant role in shaping the tumor microenvironment. By influencing the behavior of cancer cells, RhoA can affect the recruitment and activation of stromal cells, such as fibroblasts and immune cells. This interaction can create a supportive niche for tumor growth and metastasis. Additionally, RhoA-mediated changes in the extracellular matrix can alter the physical properties of the tumor microenvironment, further promoting cancer cell invasion and dissemination.
