What role does RhoA play in tumor growth and metastasis?
RhoA influences tumor growth and metastasis through several mechanisms. By regulating the actin cytoskeleton, RhoA promotes changes in cell shape and motility, facilitating invasion and migration. Additionally, RhoA activation enhances cell proliferation and survival by modulating various signaling pathways, such as the MAPK/ERK and PI3K/AKT pathways. RhoA also promotes the formation of invadopodia, which are actin-rich protrusions that degrade the extracellular matrix, enabling cancer cells to invade surrounding tissues and metastasize.
