What are the therapeutic implications of targeting RhoA in cancer?
Given the pivotal role of RhoA in cancer progression, targeting RhoA signaling offers a promising therapeutic strategy. Inhibitors of RhoA or its downstream effectors could potentially reduce tumor growth, invasion, and metastasis. Various approaches are being explored, including small molecule inhibitors, peptides, and RNA interference. However, the challenge lies in achieving specificity and minimizing off-target effects, as RhoA is also involved in essential physiological processes.
