How Does the Tumor Microenvironment Influence Integrin Function?
The tumor microenvironment, composed of ECM, stromal cells, and immune cells, plays a significant role in modulating integrin function. Cancer-associated fibroblasts and tumor-associated macrophages can alter ECM composition and stiffness, affecting integrin-mediated signaling. Additionally, hypoxia and other stress conditions within the tumor microenvironment can induce integrin expression and activation, promoting tumor survival and adaptation.
