What is the Impact of Integrin Signaling on Cancer Therapy?
Integrin signaling pathways are attractive targets for cancer therapy due to their involvement in tumor growth and metastasis. Inhibitors of integrins and their downstream signaling molecules are being explored as potential therapeutic agents. For example, monoclonal antibodies and small molecule inhibitors targeting integrins like αvβ3 and α5β1 are currently under investigation in clinical trials. Additionally, integrin inhibitors can enhance the efficacy of conventional therapies by improving drug delivery and reducing resistance to treatment.
