What are the Challenges and Future Directions in Integrin Research?
Despite the advances in understanding integrin biology in cancer, several challenges remain. The redundancy and complexity of integrin signaling pathways pose difficulties in designing specific and effective inhibitors. Moreover, the variability in integrin expression among different cancer types and stages necessitates personalized approaches. Future research should focus on elucidating the precise roles of individual integrin subunits and their interactions with other signaling networks. Integrin-targeted therapies should be optimized for selectivity and combined with other treatment modalities to enhance their clinical efficacy.
