Cancer, particularly brain tumors like gliomas, significantly alter the microstructural environment of the brain. These changes can be detected using NODDI, which measures parameters such as neurite density index (NDI) and orientation dispersion index (ODI). By analyzing these parameters, clinicians can gain a better understanding of tumor infiltration, cellularity, and the impact of the tumor on surrounding brain tissue. This information can be critical for diagnosis, treatment planning, and monitoring disease progression.
