What are Some Examples of Metabolic Pathways for Common Chemotherapeutic Agents?
Here are a few examples:
Cyclophosphamide: This prodrug is metabolized in the liver by CYP450 enzymes to its active form, phosphoramide mustard, which exerts its cytotoxic effects. 5-Fluorouracil (5-FU): Metabolized primarily in the liver by the enzyme dihydropyrimidine dehydrogenase (DPD), deficiencies in this enzyme can lead to severe toxicity. Paclitaxel: Metabolized by CYP2C8 and CYP3A4 enzymes, inhibitors or inducers of these enzymes can significantly alter its pharmacokinetics.
