What Factors Influence the Metabolism of Chemotherapeutic Agents?
Several factors can influence the metabolism of chemotherapeutic agents, including:
Genetic Variability: Genetic polymorphisms in metabolic enzymes can lead to variations in drug metabolism among individuals. For example, polymorphisms in the CYP2D6 enzyme can affect the metabolism of certain chemotherapeutic drugs. Age and Sex: Metabolic rates can vary with age and sex, influencing drug efficacy and toxicity. Organ Function: Compromised liver or kidney function can alter drug metabolism and excretion, necessitating dose adjustments. Drug Interactions: Concomitant medications can inhibit or induce metabolic enzymes, affecting the metabolism of chemotherapeutic agents.
