What are the challenges in studying CNVs in cancer?
Several challenges exist in studying CNVs in cancer: 1. Complexity and Heterogeneity: Cancer genomes are highly heterogeneous, making it difficult to distinguish driver CNVs from passenger CNVs. 2. Technological Limitations: Although detection methods have advanced, they still have limitations in sensitivity, specificity, and resolution. 3. Interpretation: Determining the functional impact of CNVs on gene expression and cancer progression remains complex.
