What is the clinical significance of CNVs in cancer?
Understanding CNVs can have significant clinical implications. CNVs can serve as biomarkers for cancer diagnosis, prognosis, and therapeutic response. For instance, the presence of ERBB2 amplification in breast cancer is used to determine the eligibility for targeted therapies like trastuzumab. Similarly, the detection of CNVs in genes like EGFR can guide precision medicine approaches in lung cancer.
