What are the Challenges in Targeting Chemokines for Cancer Therapy?
Targeting chemokines in cancer therapy presents several challenges. The redundancy and pleiotropy of chemokine functions mean that inhibiting one pathway could be compensated by another. Moreover, systemic inhibition of chemokines could impair normal immune responses and lead to side effects. Therefore, precise targeting and careful modulation of chemokine activity are crucial for the development of effective therapies.
