What Are the Challenges in Targeting Glycosylation in Cancer?
There are several challenges in targeting glycosylation in cancer: - Complexity of Glycosylation: The vast diversity and complexity of glycan structures make it difficult to target specific alterations. - Off-Target Effects: Inhibiting glycosylation enzymes can affect normal cells, leading to potential side effects. - Tumor Heterogeneity: Variability in glycosylation patterns among different tumors and even within the same tumor can complicate treatment strategies.
