What is the Impact of Aberrant Glycosylation on Cancer Progression?
Aberrant glycosylation can have multiple impacts on cancer progression: - Cell Proliferation: Modified glycosylation can alter growth factor receptor signaling, leading to uncontrolled cell growth. - Metastasis: Changes in glycosylation can enhance the ability of cancer cells to invade surrounding tissues and spread to distant sites. - Immune Evasion: Altered glycosylation can help cancer cells avoid detection and destruction by the immune system. - Cell Adhesion: Glycosylation affects cell-cell and cell-matrix interactions, influencing tumor adhesion and migration.
