What are the challenges in targeting UPR for Cancer therapy?
Despite its potential, targeting the UPR for cancer therapy presents several challenges:
Specificity: Since the UPR is also crucial for the survival of normal cells under stress, there is a risk of toxicity and side effects. Complexity: The UPR involves multiple pathways that can compensate for each other, making it difficult to achieve a complete therapeutic effect by targeting a single arm of the UPR. Resistance: Cancer cells may develop resistance to UPR-targeting drugs, necessitating combination therapies or alternative approaches.
