What Are the Clinical Implications of BUBR1 in Cancer?
The status of BUBR1 can serve as a prognostic marker in various cancers. Low levels of BUBR1 are often associated with poor prognosis and aggressive tumor behavior. Additionally, targeting the BUBR1 pathway has therapeutic potential. For instance, inhibitors of the spindle assembly checkpoint are being explored as anti-cancer agents, aiming to exploit the vulnerabilities of cancer cells with defective mitotic checkpoints.
