What are the Clinical Implications of CagA in Cancer?
Infection with CagA-positive H. pylori strains is associated with a higher risk of developing gastric cancer compared to CagA-negative strains. This association has significant clinical implications. For instance, screening for CagA can help identify individuals at higher risk for gastric cancer, leading to more targeted surveillance and early intervention. Additionally, understanding the mechanisms by which CagA induces carcinogenesis can aid in the development of novel therapeutic strategies aimed at blocking its activity.
