Molecular Initiating Event (MIE): The first interaction between a molecule and a biological system that starts the adverse outcome pathway. Key Events (KEs): Measurable changes in biological states or processes that are part of the progression toward the adverse outcome. Adverse Outcome (AO): The final, undesirable effect on health, such as the development of cancer. Key Event Relationships (KERs): Descriptions of how KEs are connected and influence one another.
