What are the Main Types of GSTs Involved in Cancer?
The GST family is divided into several classes, including Alpha, Mu, Pi, Theta, and Omega. Among these, GSTP1 (Pi class) is the most studied in the context of cancer. GSTP1 is often overexpressed in tumors and is linked to resistance to multiple chemotherapy drugs. Other isoforms, such as GSTA1 and GSTM1, also play significant roles in cancer biology.
