Doxorubicin works by intercalating DNA strands, inhibiting the enzyme topoisomerase II, which leads to DNA strand breaks and ultimately cell death. Bleomycin induces DNA strand breaks by generating free radicals, which damage the DNA and lead to apoptosis or cell death. Mitomycin C functions as an alkylating agent, cross-linking DNA and inhibiting DNA synthesis, which results in the inhibition of cancer cell proliferation.
