What are the challenges in using Streptomyces-derived agents?
Despite their effectiveness, there are some challenges associated with the use of Streptomyces-derived anticancer agents:
Toxicity: These agents can have significant side effects, such as cardiotoxicity in the case of doxorubicin, which limits its dosage and long-term use. Resistance: Cancer cells can develop resistance to these drugs, making them less effective over time. Production Challenges: The complex nature of these compounds can make large-scale production and purification difficult and costly.
