What are the Mechanisms of PTHrP Action in Cancer?
PTHrP exerts its effects through binding to the PTH/PTHrP receptor (PTH1R) on target cells. This interaction activates signaling pathways such as the cAMP-PKA pathway, MAPK pathway, and PI3K/AKT pathway. These pathways collectively contribute to cell proliferation, inhibition of apoptosis, and increased cell motility, which are critical for tumor growth and metastasis.
