What Are the Strategies to Overcome Drug Efflux-Mediated Resistance?
Several strategies have been explored to counteract drug efflux and enhance the effectiveness of chemotherapy: 1. Efflux Pump Inhibitors: These compounds inhibit the function of efflux transporters. Examples include verapamil and tariquidar, which inhibit P-gp. 2. Nanoparticle Drug Delivery: Encapsulating drugs in nanoparticles can bypass efflux pumps and increase drug accumulation in cancer cells. 3. Gene Silencing: Techniques such as RNA interference (RNAi) can be used to downregulate the expression of efflux transporter genes. 4. Combination Therapy: Using a combination of drugs, including efflux pump inhibitors and chemotherapeutic agents, can help overcome resistance.
