What Are the Clinical Implications of Drug Efflux?
The presence of efflux transporters in cancer cells can significantly impact the clinical outcomes of chemotherapy. For instance, high levels of P-gp expression are often associated with poor prognosis and reduced survival rates in patients with various cancers, including leukemia, breast cancer, and ovarian cancer. Understanding the role of drug efflux can help in the development of personalized treatment plans and more effective therapeutic strategies.
