What are the Therapeutic Implications of Targeting Senescence?
Targeting senescence presents a promising therapeutic avenue in cancer treatment. Strategies to modulate senescence include inducing senescence in cancer cells to halt their proliferation, using senolytic drugs to selectively eliminate senescent cells, and modulating the SASP to reduce its pro-tumorigenic effects. These approaches aim to leverage the protective aspects of senescence while mitigating its potential to drive tumor progression and therapy resistance.
