What Challenges Are Associated with Drug Absorption in Cancer?
One of the significant challenges in drug absorption for cancer treatment is overcoming the barriers posed by the tumor microenvironment. The dense extracellular matrix, abnormal blood vessels, and high interstitial pressure can impede drug delivery. Additionally, the expression of efflux pumps in cancer cells can actively transport drugs out of the cells, reducing their intracellular concentration and efficacy. Researchers are working on innovative approaches, such as liposomal formulations and bioconjugates, to overcome these barriers and enhance drug absorption.
