What Challenges Exist in Developing Specific Inhibitors?
Despite their promise, developing specific inhibitors is fraught with challenges:
1. Drug Resistance: Cancer cells can develop resistance to inhibitors through mutations or activation of alternative signaling pathways. 2. Tumor Heterogeneity: Cancer is often heterogeneous, meaning different cells within the same tumor can have different molecular profiles, complicating treatment. 3. Off-Target Effects: While designed to be specific, inhibitors can sometimes affect other proteins, leading to unintended side effects.
